http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101404247-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-435 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-17 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-7105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P19-10 |
| filingDate | 2010-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2014-06-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-101404247-B1 |
| titleOfInvention | Composition for improving bone formation or osteogenesis comprising an HVEM inhibitor as an active ingredient |
| abstract | More particularly, the present invention relates to a composition for inhibiting the expression of HVEM (Herpesvirus-entry mediator) gene or an inhibitor of activity of HVEM protein, which comprises an HVEM inhibitor as an active ingredient. A composition for preventing or treating bone diseases comprising the composition as an active ingredient, a method for predicting or diagnosing the onset of bone disease, a method for screening a substance for preventing or treating bone diseases, And a method of promoting bone differentiation or bone formation. In the present invention, mice lacking the HVEM gene in the animal model were found to have increased bone mass and bone formation as compared with the control mice expressing the HVEM gene, thereby promoting bone morphogenesis and reducing bone resorption Thus, the inhibitor of HVEM gene expression or the activity of HVEM protein according to the present invention can be effectively used as a therapeutic agent for bone diseases requiring bone formation or bone formation. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20200099033-A |
| priorityDate | 2010-11-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 249.