http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101384683-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2500-02 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-574 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-10 |
| filingDate | 2011-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2014-04-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-101384683-B1 |
| titleOfInvention | Peptides containing mdm2-binding motifs and uses thereof |
| abstract | The present invention provides a peptide comprising a mdm2-binding motif sequence of SEQ ID NO: 1 which can bind to mdm2 (mouse double minute 2) and inhibit its function, or a pharmaceutically acceptable salt thereof, comprising the peptide as an active ingredient. A pharmaceutical composition for treating or preventing cancer diseases, and a method for screening a therapeutic agent for cancer diseases using the mdm2-binding motif. The peptide containing the mdm2-binding motif of the present invention competitively binds to p53 at the same site as the p53 binding site on mdm2, thereby inhibiting the binding of p53 and mdm2, thereby inhibiting the function of mdm2 and activating the p53 pathway to promote cancer cell death. can do. Therefore, the peptide containing the mdm2-binding motif of the present invention can be usefully used in the design and development of drugs for the treatment or prevention of cancer diseases through mdm2 function inhibition and p53 activation. |
| priorityDate | 2011-10-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 101.