http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101378480-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_95363fc2cf0b49e7a4aef32d7cb692a1 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2300-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-7076 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K36-87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-065 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-05 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-045 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K36-87 |
| filingDate | 2012-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4ecc47c90e15cb6db1bdd4ecd469f394 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_da951df88ce6a61e2af1c660616b0f8f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_49abf4c23c873401ee3f7e04987ab321 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c25408c18bdac9f067901cda299b86c1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f92a57e4ef8b6c063f93c67ba16ea727 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_08f1cd685ceba3dac8a81005d64ec4ca http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e58565ab5a3326535a926a0abbf07577 |
| publicationDate | 2014-04-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-101378480-B1 |
| titleOfInvention | Composition for the treatment of malignant mesothelioma, including polyphenol-based compound extracted from grapes and the anticancer drug cloparabine |
| abstract | The present invention relates to a composition for treating malignant mesothelioma comprising a polyphenolic compound extracted from grapes and an anticancer agent cloparabine, and more particularly, a resveratrol and an anticancer cloparabine, a polyphenolic compound of grapes It relates to a composition for treating malignant mesothelioma. It was found that the combined administration of the polyphenolic compound resveratrol and the anticancer drug paraparabin induces a synergistic cell death against malignant mesothelial cell MSTO-211H while maintaining minimal toxicity to normal mesothelial cell Met-5A. Molecular studies have demonstrated that this mechanism is achieved by inducing the inhibition of Nrf2, Sp1 and Akt, inducing p53 activation, and inducing apoptosis by altering the transcriptional activity of regulatory genes. Resveratrol and cloparabine will be useful as therapeutic agents for new malignant mesothelioma by inhibiting various cell survival and malignant targets and inducing apoptosis. |
| priorityDate | 2012-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 188.