| abstract |
There is provided a compound having the structure of formula (I) or a pharmaceutically acceptable salt thereof, which is a phosphonate and phosphinate activator and thus useful for treating diabetes and related diseases;n n n <Formula I>n n n n n n n n ≪n n n n n n n n (In the formula, the formula II is a heteroaryl ring; R 4 is - (CH 2) n -Z- ( CH 2) m -PO (OR 7) (OR 8), - (CH 2) n Z- (CH 2 ) m -PO (OR 7 ) R 9 ,-(CH 2 ) n -Z- (CH 2 ) m -OPO (OR 7 ) R 9 ,-(CH 2 ) n Z- (CH 2 ) m -OPO (R 9 ) (R 10 ) or — (CH 2 ) n Z— (CH 2 ) m —PO (R 9 ) (R 10 ); R 5 and R 6 are independently selected from H, alkyl and halogen; Y is R 7 (CH 2 ) s or absent; X, n, Z, m, R 4 , R 5 , R 6 , R 7 and s are as defined herein).n n n Also provided are methods of treating diabetes and related diseases using the compounds.n n n Glucokinase activators, phosphonates, phosphinates, diabetes |