http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101371698-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-7028 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K49-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B82Y5-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K49-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-127 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-48 |
| filingDate | 2011-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2014-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2014-03-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-101371698-B1 |
| titleOfInvention | Bifunctional liposomes for diagnosis and treatment and preparation method thereof |
| abstract | The present invention relates to therapeutic and diagnostic dual function liposomes comprising a complex of transition metal elements and negatively charged chemicals. The bifunctional liposome of the present invention enables simultaneous diagnosis and drug treatment using MRI. The bifunctional liposome of the present invention can enhance the sharpness and accuracy of an image for cancer diagnosis using a relatively small amount of contrast agent. The bifunctional liposomes of the present invention utilize liposomes, which are well-known as targeted drug carriers, as contrast carriers, and the MRI contrast agent, a transition metal, is encapsulated with liposomes along with negatively charged chemicals to simultaneously perform targeted imaging of cancer tissues with drug treatment. Make it workable. The present invention is based on the principle of forming a complex of a transition metal and a negatively charged chemical that can form a chelate complex with the transition metal, a transition metal contrast agent and a transition metal contrast agent using a remote method of encapsulating a negatively charged chemical by a transition metal in liposomes A negatively charged chemical (eg doxorubicin) is effectively encapsulated together in the liposome. The present invention can overcome the shortcomings of the transition metal contrast agent in the body toxicity, short blood vessel residence time and thereby the body toxicity by continuous administration, and at the same time to see the drug delivery process and therapeutic effect of cancer tissue. |
| priorityDate | 2011-06-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 53.