| abstract |
The present invention provides stable metastin derivatives having excellent biological activity (cancer metastasis inhibiting activity, cancer growth inhibitory activity, gonadal stimulating hormone secretion stimulating activity, sex hormone secretion stimulating activity and the like). By replacing the constituent amino acid of metastine with a specific amino acid in the metastine derivative of the present invention, blood stability, solubility, etc. are improved, gelation tendency is reduced, pharmacokinetics are also improved, excellent cancer metastasis inhibiting activity or cancer growth inhibition Activity appears. Moreover, the metastin derivatives of the present invention have effects such as suppressing gonadal stimulating hormone secretion and suppressing sex hormone secretion. |