| abstract |
The present invention relates to an arylcyclohexyl ether of a dihydro- tetraaza benzoazulene derivative of the formula (I), namely 5,6-dihydro-4H-2,3,5,10b-tetraaza-benzo [e] azulene derivative Arylcyclohexyl ether, a method for preparing the same, a pharmaceutical composition containing the same, and a use of the compound as a medicament: Formula I In this formula, R 1 , R 2 and R 3 are as described herein. The compounds according to the invention act as Vla receptor modulators, in particular Vla receptor antagonists. The active compounds of the present invention are dysmenorrhea, male or female sexual dysfunction, hypertension, chronic heart failure, inappropriate secretion of vasopressin, cirrhosis, nephrotic syndrome, anxiety, depressive disorder, obsessive compulsive disorder, autism spectrum disorder, schizophrenia and aggressive behavior It is useful as a therapeutic agent that acts peripherally and centrally in the symptoms of. |