abstract |
Herein are defined compounds of formula (I) and pharmaceutically acceptable salts and esters thereof. (I) Wherein, R 1 is the following formula II or formula III; <Formula II> (III) In the formula, R 2, R 4 and R 6 -9 are as defined herein. These compounds inhibit PI3 kinase and mTOR and can be used to treat PI3 kinase and mTOR mediated diseases such as various cancers. Methods of making and using the compounds of the present invention are disclosed. Various compositions containing the compounds of the present invention are also disclosed. |