| abstract |
The present invention relates to an anticancer nanoparticle having a characteristic of improving target targeting to cancer tissues and a method for preparing the same, and more specifically, to an anticancer agent and a nanoparticle base, serum albumin and a targeting agent to a porphyrin-based compound are non-covalently. It relates to a target-oriented amplification-type anticancer nanoparticles and a method for preparing the same. Target-oriented amplification-type anticancer nanoparticles according to the present invention, since the three components are non-covalently composed of an anticancer agent, a base serum albumin, a target-oriented substance porphyrin, the toxic side effects that are common in anticancer nanoparticles, It is possible to prevent the decrease in target orientation, the nanoparticles are more stabilized, a large amount of target-oriented substances are attached to the nanoparticles without changing the chemical structure, and the chemical structure of the target-directing material porphine is not modified at all, so the porphyrin-specific activity Oxygen-forming function is alive and has the effect of amplifying cancer target orientation during electromagnetic wave irradiation. The combined effects of the above-described target-oriented amplification nanoparticles of the present invention can maximize the cancer delivery rate / targeting rate of the anticancer agent, it can be expected effective treatment in early and late stage cancer. |