| abstract |
Substituted cycloalkene derivatives represented by the general formula (I) having a function of inhibiting cellular responses such as intracellular signal transduction or cell activation caused by endotoxin, and excessive production of inflammatory mediators resulting therefrom, pharmacologically A medicament containing the substituted cycloalkene derivative as an active ingredient, which is excellent in the prevention and / or treatment of acceptable salts, their preparation, and diseases such as sepsis (septic shock, disseminated intravascular coagulation syndrome, multi-organ failure, etc.) To provide.n n n General formula (Ⅰ):n n n n n n n n {Wherein,n n n X and Y represent the group etc. which form ring A with the carbon atom of the ring B to which they couple | bond.n n n 1 and m respectively independently represent the integer of 0-3, and l + m is 1-3.n n n R 1 Is an aliphatic hydrocarbon group which may be substituted. n represents the integer of 0-3.n n n R < 2> is a hydrogen atom, the alkyl group which may be substituted, etc. R < 3> Is a phenyl group which may be substituted, and R < 5> is a hydrogen atom, the alkyl group which may be substituted, etc.} |