| abstract |
Compositions for topical application of botulinum toxin (including botulinum toxin derivatives) include carriers comprising botulinum toxin and long-chain polypeptides or non-peptide polymers with positively charged branched or "efficiency groups" attached thereto. do. The invention also provides for the application of an effective amount of botulinum toxin and carrier to the subject's skin or epithelium topically to treat muscle paralysis and other symptoms that can be treated with botulinum toxin, particularly subcutaneous muscle, most particularly facial muscle paralysis. It is about how to alleviate it. Kits for administration are also described. |