| abstract |
The present invention provides polynucleotide adjuvant (PICKCa) compositions and methods of use for inducing immune responses, in particular mucosal immune responses. The polynucleotide adjuvant comprises polyriboninosinic acid-polyribocytidylic acid (PIC), at least one antibiotic and at least one positive ion. The present invention also provides immunogenic compositions comprising a polynucleotide adjuvant composition together with other immunogenic compositions such as antigens (eg, as in vaccines). The present invention further contemplates the use of such adjuvant compositions, in particular in the induction of immune responses, in particular of mucosal immune responses of antigenic compounds. n n Polynucleotide adjuvant, immunogenic composition, mucosal immune response |