| abstract |
Compositions and methods for modulating an immune response in a subject are described. More specifically, human antibodies that modulate the activity of NK cells and allow for enhanced NK cell cytotoxicity in mammalian subjects, and antibodies with antibody binding properties similar to human monoclonal antibodies 1-7F9 or 14F1, are described. Also described are fragments and derivatives of such antibodies, as well as pharmaceutical compositions comprising for use in therapy, as described above and their use, particularly to increase NK cell activity or cytotoxicity in a subject.n n n NK cell, cytotoxicity, immune response, antibody fragment |