| abstract |
The present invention relates to humanized FcγRIIB antibodies or fragments and variants thereof that specifically bind to human FcγRIIB with greater affinity than the antibody binds to FcγRIIA. The present invention includes the use of the humanized antibodies of the present invention for the treatment of any disease related to loss of balance of Fc receptor mediated signaling, eg cancer, autoimmune diseases and inflammatory diseases. The present invention provides a method of enhancing the therapeutic effect of a therapeutic antibody by administering the humanized antibody of the invention to enhance the effector function of the therapeutic antibody. The invention also provides a method of enhancing the efficacy of a vaccine composition by administering a humanized antibody of the invention. The present invention includes a method for treating an autoimmune disease and a method for removing cancer cells expressing FcγRIIB.n n n n Humanized Antibodies, Antibody Fragments, Cancer, Vaccine Compositions, FcγRIIA, FcγRIIB |