| abstract |
The present invention provides an antibody that binds to an IL-18 binding protein, specifically human interleukin-18 (hIL-18). More specifically, the present invention relates to antibodies that are completely human antibodies. Preferred antibodies are antibodies that have a high affinity for hIL-18 and / or neutralize hIL-18 activity in vitro and in vivo. The antibody of the present invention may be a full length antibody or antigen binding portion thereof. Also provided are methods of making and using the antibodies of the invention. The antibodies or portions of antibodies of the invention are useful for detecting hIL-18 and for inhibiting hIL-18 activity in human subjects, such as, for example, diseases in which hIL-18 activity is detrimental. |