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filingDate 2013-02-28-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2013-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b49677a845243272aecf9a10c829533e
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publicationDate 2013-06-17-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber KR-101275267-B1
titleOfInvention Composition for diagnosing metastatic characteristics of ovarian cancer using cpg methylation status in promoter region of ca9 gene and uses thereof
abstract PURPOSE: A composition for diagnosing metastatic ovarian cancer using CpG methylation change of a CA9(carbonic anhydrase 9) gene promoter, and a use thereof are provided to measure methylation levels of a certain gene promoter site of genome DNA collected from a patient's sample by MSP(Methylation-Specific PCR), to quickly diagnose the risk of metastasis, and to develop a convenient diagnostic kit. CONSTITUTION: A composition for diagnosing ovarian cancer metastasis or predicting the risk of metastasis contains an agent which measures methylation levels of a CpG site of a CA9 gene promoter. The agent contains: a compound which changes non-methylated cytosine or a methylation-sensitive restriction enzyme; a primer which is specific to a methylated sequence of an AGR2 gene promoter; and a primer which is specific to a non-methylated sequence of the AGR2 gene promoter. A method for providing information for diagnosing ovarian cancer metastasis or predicting the risk of metastasis comprises: a step of measuring the methylation level of the CpG site of the CA9 gene promoter from a patient's sample; and a step of comparing methylation levels with a control group.
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