| abstract |
The present invention relates to compounds of formula (I) which inhibit protein tyrosine kinases, in particular c-fms kinases, and solvates, hydrates, tautomers and pharmaceutically acceptable salts thereof:n n n n n n n n Wherein A, X, R 2 and W are as described herein.n n n Treating autoimmune diseases and diseases with inflammatory components; To treat metastasis of ovarian cancer, uterine cancer, breast cancer, colon cancer, gastric cancer, hair cell leukemia and non-small cell lung cancer; Treating skeletal pain caused by tumor metastasis or osteoarthritis, or pain including intestinal, inflammatory, and neuropathic pain; Also provided are methods for treating osteoporosis, Paget's disease, and other diseases that mediate bone resorption, including arthritis, artificial joint disorders, osteolytic sarcomas, myeloma, and tumor metastasis to bone. |