http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101260453-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2030-025 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-25 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-743 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N30-7206 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-25 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-74 |
| filingDate | 2011-09-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2013-05-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-101260453-B1 |
| titleOfInvention | Simultaneous Analysis of Multiple Cytochrome P450 Enzyme Activity in Mass Spectrometry-based Biological Samples |
| abstract | The present invention relates to an analytical method capable of simultaneously measuring and comparing the activity of various types of cytochrome P450 enzymes involved in the hydroxylation metabolism of steroid hormones in a biological sample using a mass spectrometer. The present invention shows the activity change of various types of cytochrome P450 enzymes related to steroid hormone metabolism according to drug administration from biological samples such as urine as concentration ratios between the metabolites, which can be measured simultaneously in one pretreatment and analysis. have. Therefore, it is possible to evaluate drug efficacy and metabolic mechanism as a whole by changing cytochrome P450 enzyme activity according to specific drug intake, and also use it as an analysis technology capable of cross-validation with cytochrome P450 enzyme analysis based on drug genome. Can be. In addition, their accumulated information can be widely applied in the study of new drugs and drug metabolism as well as diseases related to the activity of cytochrome P450 enzymes. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20180128314-A |
| priorityDate | 2011-09-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 580.