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filingDate 2010-10-04-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2013-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2013-04-16-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber KR-101255337-B1
titleOfInvention Nitrogen Monoxide Carrier Using Temperature Sensitive Synthetic Polymer
abstract A polymer carrier capable of controlled release of nitric oxide is disclosed. The nitrogen monoxide carrier of the present invention is a polymer molecule comprising a main chain of an organic polymer and a side chain covalently linked to the main chain and having a diazenium dioleate functional group. Nitrogen monoxide controlled release carrier of the present invention exists in a fluid state such as a liquid at room temperature, such as a liquid, but when the temperature rises above the threshold temperature in vivo pH causes a phase transition from sol to gel, the critical temperature of the phase transition is 25 ~ It is in the range of 35 ° C., and the gel is a hydrogel made without chemical crosslinking. In addition, the present invention discloses an artificial body insert coated with the surface of the nitrogen monoxide controlled release carrier.
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