| abstract |
The present invention provides a method of treating bone cancer, in particular metastatic bone cancer, by administering an IGF-IR antagonist and / or a PDGFRα antagonist. The present invention also provides antibodies that bind to human PDGFRα and neutralize the activity of the receptor. The present invention further provides methods of neutralizing the activation of PDGFRα using antibodies alone or in combination with other agents, and methods of treating mammals with neoplastic disease.n n n n IGF-IR antagonists, PDGFRα antagonists, antibodies, antibody fragments, anticancer |