http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101245111-B1
Outgoing Links
Predicate | Object |
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classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6884 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6893 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1135 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-12 |
filingDate | 2010-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2013-03-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2013-03-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | KR-101245111-B1 |
titleOfInvention | A radiation sensitive marker comprising an HM18 gene or an expression protein thereof, or a protein regulated by the reduction of the gene expression |
abstract | The present invention relates to a radiation-sensitive marker and a medical use thereof comprising the HMG17 gene or its expression protein, or a protein regulated by the reduction of the expression of the gene, and when the amount of expression of the HMG17 gene decreases, the radiation sensitivity of the cell increases. As more cells die, the expression of Chk2 and p-ATM decreases as the amount of HMG17 gene decreases as a result of the increase of cell death, thereby reducing the expression of the HMG17 gene or its expression protein, the HMG17 gene. Chk2 and p-ATM, which are proteins whose expression is reduced, can be used as markers for evaluating radiation sensitivity, and at the same time, a composition for enhancing radiation sensitivity can be developed using these inhibitors. Furthermore, the combination of radiation therapy with reduced expression of HMG17, Chk2 or p-ATM can increase the sensitivity of cancer cells to radiation, thereby inhibiting the growth of cancer cells. Therefore, radiation therapy has been shown to be effective in various cancer diseases such as lung cancer or osteosarcoma. Can be promoted. |
priorityDate | 2010-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 811.