http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101243367-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5011 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0693 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N13-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-02 |
| filingDate | 2010-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-03-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2013-03-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-101243367-B1 |
| titleOfInvention | Screening methods for substances that enhance the radiation sensitivity of radiation non-reactive cancer cells |
| abstract | The present invention comprises the steps of (a) contacting a radioactive non-reactive cell line lacking the function of a gene encoding TERC and a constitutive protein of telomerase and a gene encoding a cancer suppressor, (b) irradiating with radiation (C) measuring the level of colony formation in the cell line, and (d) selecting candidates whose degree of colony formation in step (c) is reduced compared to the control group that did not process the candidates. The present invention relates to a method for screening a substance that enhances radiation sensitivity of radiation non-reactive cancer cells. In addition, the present invention (a) contacting a radioactive non-reactive cell line and a radiation-reactive cell line with a gene encoding TERC, a constitutive protein of telomerase, and a function of a gene encoding a cancer suppressor, with a candidate, ( b) irradiating with radiation, (c) measuring the level of colony formation in said cell line, and (d) selecting candidates for which the degree of colony formation in step (c) is similar to a radiation reactive cell line; The present invention relates to a method for screening a substance that enhances radiation sensitivity of radiation non-reactive cancer cells. The screening method of the present invention is to improve the radiation sensitivity of tumor cells to DNA damage factors such as anticancer agents or radiation to select a substance that maximizes the apoptosis effect of the tumor cells by using as a chemotherapy in combination with radiation therapy or chemotherapy Effective chemotherapy is possible. |
| priorityDate | 2010-12-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 73.