| abstract |
An object of the present invention is to provide a method capable of inducing a humoral immune response with high efficiency when producing antibodies to antigenic proteins by gene immunity. By administering to the animal a fusion gene linked to a gene encoding all or part of an antigenic protein and a gene encoding a chaperonin subunit or chaperonin subunit linkage, the expression of the fusion gene in the animal is expressed. Induces a humoral immune response to As an example of chaperonin, E. coli GroEL is mentioned. Immunization compositions, methods for producing antibodies, methods for producing hybridomas, and methods for producing monoclonal antibodies are also provided.n n n n Gene immunity, humoral immunity, chaperonin, monoclonal antibodies |