| abstract |
Antibodies that bind to the novel PSCA proteins and molecules derived therefrom, and variants thereof, are described wherein PSCA is tissue specific in normal adult tissues and aberrantly expressed in the cancers shown in Table I. As a result, PSCA provides a diagnostic, prognostic, prophylactic and / or therapeutic target for cancer. PSCA genes or fragments thereof, or proteins they encode or variants thereof, or fragments thereof can be used to elicit a humoral or cellular immune response; Antibodies or T cells that react with PSCA can be used in either active or passive immunization.n n n PSCA, tumor, cancer |