| abstract |
The present invention is formulan n n n n n n n Wherein,n n n A ring represents a carbocyclic group or a heterocyclic group,n n n X 1 represents a hydrogen atom, a lower alkyl group, an amino group, or the like,n n n X 2 represents a hydrogen atom or a lower alkyl group,n n n Y represents a direct bond or a sulfur atom or a nitrogen atom,n n n n represents an integer of 0 to 4,n n n Ar is the following formulan n n n n n n n Represents a group ofn n n The present invention provides a pyrimidine derivative or a salt thereof useful in the treatment, treatment, and the like of a disease such as IBS, with both actions of 5-HT 1A agonism and 5-HT 3 antagonism.n n n Furthermore the present invention is that the administration of a 5-HT 3 antagonist having a working action on the 5-HT 1A, or 5-HT 1A agonist and 5-HT 3 antagonist, at the same time, will be administered a couple of sequential or interval It is to provide a method for the treatment of IBS, characterized in that the simultaneous co-operation of 5-HT 1A action and 5-HT 3 antagonism in vivo.n n n Pyrimidine derivatives |