| abstract |
The present invention relates to a process for purifying fibrinogen, comprising one or more process steps wherein one or more contaminating proteins are depleted by negative chromatography and / or negative adsorption using cation exchangers, hydrophobic gels and / or dye gels. The present invention also relates to fibrinogen obtained by the method of the present invention and markedly improved in stability, and to a method for preparing and using a pharmaceutical formulation comprising the fibrinogen.n n n n Fibrinogen, contaminating proteins, cation exchangers, hydrophobic gels, dye gels, negative adsorption, fibrinogen preparations, negative chromatography |