| abstract |
Auristatin peptides, including MeVal-Val-Dil-Dap-noraphedrine (MMAE) and MeVal-Val-Dil-Dap-Phe (MMAF), have been prepared and used in a variety of linkers including maleimidocaproyl-Val- Lt; / RTI > to the ligand. The resulting ligand drug conjugate is active in vitro and in vivo.n n n n Drug-linker-ligand conjugate, drug-linker compound, drug-ligand conjugate, cancer disease, autoimmune disease, infectious disease |