| abstract |
The present invention relates to bipyrimidinyl diphosphine compounds of formula (I), enantiomers thereof or enantiomeric mixtures thereof.n n n <Formula I>n n n n n n n n Wheren n n R is optionally substituted alkyl, cycloalkyl, aryl or heteroaryl;n n n R ′ and R ″ are independently optionally substituted alkyl, cycloalkyl, aryl or heteroaryl.n n n The compounds of formula (I) are chiral atropisomer bipyrimidyl diphosphine compounds and thus can be used as ligands to generate chiral transition metal catalysts which can be applied to various asymmetric reactions such as palladium catalyzed asymmetric allyl substitution reactions. According to the methods disclosed herein, the compounds of the present invention can be readily obtained with high enantiomeric purity.n n n Bipyrimidinyl diphosphine, enantiomers, chiral transition metal catalysts |