abstract |
The present invention provides a dose volume of an immunogenic influenza composition suitable for human use, comprising an adjuvant composition comprising an influenza virus antigen or antigenic preparation thereof, and an oil-in-water emulsion, wherein the oil-in-water emulsion is less than 11 mg. Levels of metabolizable oil and less than 5 mg of emulsifier, and optionally less than 12 mg of tocol or sterol. Suitably, the amount of influenza antigen per strain per dose is a small amount such as 15 μg HA or less than 15 μg HA. |