http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101179012-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-81 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-75 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-75 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D213-61 |
| filingDate | 2004-03-08-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2012-09-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2012-09-03-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-101179012-B1 |
| titleOfInvention | Roflumirast New Manufacturing Method |
| abstract | The present invention relates to a novel process for producing high purity roflumilast. The method comprises reacting a 4-amino-3,5-dichloropyridine anion of Formula 1 with 3-cyclopropylmethoxy-4-difluoromethoxybenzoic acid active derivative of Formula 2, wherein 3-cyclopropyl The molar ratio of 4-amino-3,5-dichloropyridine anion used with respect to the methoxy-4-difluoromethoxybenzoic acid active derivative is 1.5 or more and 3 or less, preferably 1.8 or more and 2.7 or less, more preferably 2 or more and 2.5 And more particularly preferably 2.2.n n n Formula 1n n n n n n n n (2) |
| priorityDate | 2003-03-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 20.