http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101166280-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-87 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D307-81 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C255-59 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D307-81 |
| filingDate | 2005-08-12-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2013-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2013-11-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-101166280-B1 |
| titleOfInvention | Process for preparing citalopram and enantiomers |
| abstract | The present invention relates to the reaction of 1- [3- (dimethylamino) propyl] -1- (4-fluorophenyl) -1,3-di comprising reacting a compound of Formula IVa with a compound of Formula RX in the presence of a base. To a method for preparing hydro-5-isobenzofuran carbonitrile, wherein RX is also selected so that a compound of formula Va, an intermediate ether derivative formed from the reaction, can be cyclized to form a compound of formula VI: , If Z is not a cyano group, convert the group Z to a cyano group in the compound of formula VI to Form hydro-5-isobenzofuran carbonitrile:n n n IVan n n n n n n n The formula Van n n n n n n n VIn n n n n n n n Wheren n n R is selected from alkyl, alkenyl, aryl and heteroaryl, which may be optionally substituted with an electron withdrawing group,n n n X is selected from F, Cl, Br, I, CN, OTf and OR 1, where Tf represents a trifluoromethanesulfonyl group, R 1 is optionally substituted alkyl,n n n Z is a group which may be converted to a cyano group or a cyano group.n n n The present invention also provides novel ether compounds, compounds of formula Va and methods for their preparation. |
| priorityDate | 2004-08-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 16.