abstract |
A particle suitable for delivery from a particle mediated delivery device is provided. The particles are obtained by depositing nucleic acids on inert metal carrier particles in the presence of a nucleic acid condensing agent and a metal ion chelating agent. Also described are methods of treatment using the particles, including methods of making the particles and methods of nucleic acid immunization and gene therapy.n n n Particle mediated delivery devices, nucleic acid condensing agents, metal ion chelating agents, inert metal carrier particles, gene therapy |