| abstract |
The present invention relates to chronic obstructive pulmonary disease (COPD), asthma, chronic bronchitis, psoriasis, ulcerative colitis, Crohn's disease (local ileitis), atherosclerosis, rheumatoid arthritis, osteoporosis, osteoarthritis, depression, memory impairment, inflammation mediated inflammation Novel 1 H -pyridin-2-one derivatives, pharmaceutically acceptable salts thereof, and stereochemical isomers, useful for the treatment of sexual chronic histopathy and other diseases mediated by PDE4. |