http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101123178-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4436 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D409-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-381 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-68 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D333-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-501 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-54 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D409-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D333-68 |
| filingDate | 2009-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2012-06-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2012-06-13-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-101123178-B1 |
| titleOfInvention | 2-arylbenzothiophene derivative or pharmaceutically acceptable salt thereof, preparation method thereof, and pharmaceutical composition for diagnosis or treatment of degenerative brain disease containing the same as an active ingredient |
| abstract | The present invention relates to a 2-arylbenzothiophene derivative represented by the following Formula 1 or a pharmaceutically acceptable salt thereof, a method for preparing the same, and a pharmaceutical composition for diagnosing or treating degenerative brain disease containing the same as an active ingredient. Since the derivative represented by Chemical Formula 1 strongly binds to β-amyloid, it can be used as a diagnostic reagent for early diagnosis of Alzheimer's disease in a non-invasive way when labeled with radioisotopes, and the low molecular weight β- Since the combination with the amyloid peptide conjugate inhibits the production of malignant polymer β-amyloid precipitate, the pharmaceutical composition containing the derivative of the present invention as an active ingredient can be usefully used as a therapeutic agent for degenerative brain diseases such as Alzheimer's disease.n n n [Formula 1]n n n n n n n n (Wherein R 1 to R 4 , V, W, X, Y and Z are as defined in the specification)n n n 2-arylbenzothiophene, β-amyloid, Alzheimer's disease, degenerative brain disease, radiopharmaceutical |
| priorityDate | 2009-04-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 43.