| abstract |
The present invention provides a drug delivery comprising one or more compartments comprising (i) a drug loaded thermoplastic polymer core, (ii) a drug loaded thermoplastic polymer interlayer and (iii) a drug-free thermoplastic polymer epidermis covering the interlayer. The system, wherein the interlayer comprises (a) a first pharmaceutically active substance in crystalline form and (b) a second pharmaceutically active substance in soluble form, wherein the core is filled with a second active substance in soluble form To provide. |