Predicate |
Object |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-41 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-53 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-111 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-732 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2869 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y204-01068 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1137 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-85 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-07 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 |
filingDate |
2007-12-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate |
2012-02-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate |
2012-02-29-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
KR-101114741-B1 |
titleOfInvention |
SHRNA-Regulated Inhibition of Alpha-1,6-fucosyl Transferase Expression |
abstract |
The present invention comprises the steps of culturing a mammalian cell under conditions suitable for expression of a heterologous polypeptide; And recovering the heterologous polypeptide from the mammalian cell or culture, wherein the enzymatic activity of α1,6-fucosyl transferase in mammalian cells is targeted by shRNA targeting α1,6-fucosyl transferase mRNA. A method of making a heterologous polypeptide with reduced fucose modification in a mammalian cell is reduced. |
priorityDate |
2006-12-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |