| abstract |
The present invention relates to ligands that specifically bind to TNFR1 including IGFBP-5 proteins, variants, fragments, and uses thereof. More specifically, the present invention relates to IGFBP-5 proteins, variants, fragments, genes encoding them, and the genes. It relates to a TNF-α inhibitor and a cell death promoter comprising a recombinant expression vector or a transformant comprising the recombinant expression vector as an active ingredient. According to the present invention, the IGFBP-5 protein is a protein present in the human body, and thus prevents various diseases such as inflammatory diseases caused by overexpression of TNF-a and various cancers without side effects that may occur in synthetic drugs. And treatment will be possible.n n n n IGFBP-5, TNF-α, TNFR1 |