| abstract |
Provided are agents for topical administration that are effective as anti-allergic agents.n n n Formula 1:n n n [Formula 1]n n n n n n n n [In the meal,n n n Ring A contains 6 to 10 membered monocyclic or bicyclic aromatic carbocyclic rings or 1 to 3 heteroatoms selected from 0 to 2 nitrogen atoms, 0 or 1 oxygen atom, and O or 1 sulfur atom Represents a 5 to 10 membered monocyclic or bicyclic aromatic heterocycle, n represents an integer of 0 to 2, M represents an integer of 0 to 2, R represents a halogen atom or a substituted or unsubstituted alkyl group, or the like. X 1 represents an oxygen atom, a sulfur atom, NR 1 (R 1 represents a hydrogen atom or an alkyl group) or a single bond, Y 1 represents a single bond or an alkylene, and Y 2 represents a single bond. Or alkylene and the like, Z represents alkylene, and one or more of Q 1 and Q 2 represents -COOR 10 (wherein R 10 represents a substituted or unsubstituted alkyl group or the like) and the like. Adenine compounds or pharmaceutically acceptable salts thereof Medicament for topical administration which contains as. |