| abstract |
The present invention relates to a novel compound represented by formula (I).n n n n n n n n Wherein M is a macrolide subunit of formula (II), L is a chain of formula (III), and D represents a steroid or nonsteroidal subunit derived from a nonsteroidal drug (NSAID) with steroid or anti-inflammatory activity . The present invention also relates to pharmaceutically acceptable salts and solvates of the compounds, to methods of preparing the compounds and to intermediates therefor. The present invention also relates to the improved therapeutic activity of the compounds and their use to treat inflammatory diseases and conditions in humans and animals.n n n n n n n n n n n n n Macrolides, steroids or nonsteroidal subunits, complexes |