abstract |
Stereoisomeric pure (+)-2- [1- (3-ethoxy-4-methoxyphenyl) -2-methylsulfonylethyl] -4-acetylaminoisoindolin-1,3-dione, substantially Free of its (-) isomers or to pharmaceutically acceptable prodrugs, metabolites, polymorphs, salts, solvates, hydrates or clathrates thereof. In addition, (+) enantiomer of 2- [1- (3-ethoxy-4-methoxyphenyl) -2-methylsulfonylethyl] -4-acetylaminoisoindoline-1,3-dione It relates to a pharmaceutical composition comprising and a method of using the same. The present invention also relates to a method for treating and preventing a disease by inhibition of TNF-α or PDE4. |