| abstract |
The present invention relates to compounds of formula (I) and pharmaceutically acceptable acid addition salts thereof:n n n [Formula I]n n n n n n n n Wheren n n Is a 5 or 6 membered aromatic or heteroaromatic ring,n n n R 1 is cycloalkyl, or aryl or heteroaryl, wherein one or more rings are unsubstituted or substituted with halogen, lower alkyl, halogen, lower alkyl, lower alkoxy, lower alkoxy substituted with halogen, -C (O)- A lower aromatic group, -S (O) 2 -lower alkyl group, aromatic group, substituted with 1 to 3 substituents selected from the group consisting of cyano,n n n R 2 is hydrogen or lower alkyl,n n n R 3 is hydrogen or lower alkyl,n n n R 4 is halogen, lower alkyl, lower alkyl substituted by halogen, lower alkoxy, lower alkoxy substituted by halogen, or nitro,n n n R 5 is hydrogen, halogen, lower alkyl, or lower alkyl substituted with halogen,n n n X is a bond,-(CH 2 ) m- , -CH 2 O- or -CH 2 NH-,n n n The dotted line indicates that it is bonded or non-bonded,n n n n is 1 or 2,n n n m is 1, 2 or 3. |