| abstract |
The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof:n n n Formula In n n n n n n n Wheren n n X is a bond, -CH 2 CH 2- , -CH = CH-, -CH 2 O-, -CH 2 NR-, -CH 2 S (O)-, CH 2 S (O) 2- , -O- , OCH 2 CH 2 S (O) 2- , -CH 2 NRCO-, -CH 2 NRCH 2- , , -NRS (O) 2 NR-, -NHCHR- or -NRS (O) 2- , X can be inserted in both directions of the compound of formula (I);n n n Y is a bond, -CHR- or -OCH 2 CH 2- ;n n n R is hydrogen or lower alkyl;n n n Ar 1 and Ar 2 are independently of each other aryl or 5- to 10-membered heteroaryl, lower alkyl, lower alkoxy, lower haloalkoxy, halogen, -CF 3 , -CH 2 OH, -CH 2 O-lower alkyl, 3- to 10-membered cycloalkyl, 5- to 10-membered heterocycloalkyl, -CH 2 O (CH 2 ) 2 O-lower alkyl, -S (O) 2 -lower alkyl, or -S (O) 2 NHR Optionally substituted. |