http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101087017-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2800-52 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-4993 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61Q19-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-447 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-4893 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-64 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K8-46 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61Q15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-183 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-26 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-42 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-16 |
| filingDate | 2008-05-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2011-12-09-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-101087017-B1 |
| titleOfInvention | Pharmaceutical Liquid Compositions with Improved Stability of Botulinum Toxin |
| abstract | The present invention relates to a pharmaceutical liquid composition having improved stability of botulinum toxin, and provides a pharmaceutical liquid composition comprising botulinum toxin, polysorbate 20, and methionine. The present invention also provides a pharmaceutical liquid composition comprising botulinum toxin, polysorbate 20, methionine, and isoleucine.n n n The pharmaceutical liquid composition of the present invention uses a combination of methionine or methionine and isoleucine as an amino acid and polysorbate 20 as a surfactant instead of albumin or gelatin, an animal-derived protein as a stabilizer of botulinum toxin, and a botulinum toxin pharmaceutical composition as a surfactant. Patients to be administered can reduce the potential risk of infecting blood-derived pathogens or infectious microorganisms and can increase safety for the human body. In addition, the pharmaceutical liquid composition of the present invention can be conveniently used by the user because it is in liquid form when it is to be administered to a patient. In addition, since the pharmaceutical liquid composition of the present invention has superior storage stability in the liquid state than the case of using only surfactant or amino acid alone, the activity of botulinum toxin is maintained for a long time at room temperature of 25 to 37 ° C as well as refrigeration conditions. There is an advantage that can have storage stability even in an emergency where conditions cannot be maintained.n n n Clostridium, botulinum toxin, surfactant, polysorbate, amino acid, methionine, isoleucine, albumin, stabilizer |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20200066152-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20180123459-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101997615-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102259423-B1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3777837-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/EP-3782605-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20220046507-A |
| priorityDate | 2007-07-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 76.