| abstract |
The present invention relates to a non-peptidic substituted benzazine of formula (I), which includes, among others described, vasopressin, including congestive heart failure, hyponatremia, and heart failure including hypertension and increased vascular resistance. It is useful as a vasopressin receptor antagonist for the treatment of abnormalities associated with receptor activity. Pharmaceutical compositions comprising compounds of formula (I) and hypertension, congestive heart failure, heart failure, cardiovascular spasm, cardiac ischemia, cirrhosis, hyponatremia, renal vasospasm, renal failure, diabetic nephropathy, cerebral edema, cerebral ischemia It also describes how to treat abnormalities such as stroke, thrombosis, and water retention. |