http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101086138-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10T436-105831 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-00 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-805 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-06 |
| classificationIPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-805 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-16 |
| filingDate | 2003-12-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2011-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-101086138-B1 |
| titleOfInvention | Modified Hemoglobin and Method of Making the Same |
| abstract | The present invention is a hemoglobin molecule (Hb) having 6 ± 1 PEG chains, two of which are bound to Cys-93 (β) of Hb and the other PEG chains are on ε-NH 2 of Hb. It provides Hb bound to the introduced thiol group. In addition, the present invention provides a method comprising the steps of: (a) reacting Hb with an 8 to 15-fold excess of iminothiolane to form thiolated Hb, and (b) 16-fold to functionalized thiolated Hb with a maleimide moiety. Provided is a method of making a modified hemoglobin molecule (Hb) comprising reacting with a 30-fold excess of PEG to form a modified Hb.n n n n Hemoglobin, Hb, oxygen affinity, iminothiolane, PEG chain, thiolation |
| priorityDate | 2002-12-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 47.