http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101085954-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K36-483 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A23L33-105 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K36-483 |
| filingDate | 2008-07-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2011-11-22-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-101085954-B1 |
| titleOfInvention | Composition for the prevention or treatment of aberrant proliferative vascular disease comprising engraver thorn extract |
| abstract | The present invention relates to a composition for the prevention or treatment of aberrant proliferative vascular disease comprising a sculpted thorn extract as an active ingredient. Composition of the present invention comprising a bark thorn extract as an active ingredient exhibits excellent cytotoxicity against smooth muscle cells, G2 / M stage by inhibiting the expression and activity of cell cycle regulators Cdc25c, Cdc2 and cyclin B It inhibits the activity of the transcription factors NF-κB and AP-1 and inhibits the activity of MMP-9 in smooth muscle cells, effectively inhibiting the migration of cells, and also inhibiting MAPK (mitogen-) such as ERK, p38MAP kinase and JNK. Induces apoptosis of cells by promoting the activity of activated protein kinase. In addition, the composition of the present invention is excellent in safety because it contains a bark thorn extract has been used as a herbal medicine as an active ingredient for a long time.n n n n Aberrant vascular disease, smooth muscle cells, arteriosclerosis, engraver, MMP-9, cell cycle, MAPK |
| priorityDate | 2008-07-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 106.