abstract |
The present invention relates to the use of viruses, preferably adenoviruses, for the manufacture of a medicament. The virus encodes an oncogene or oncogene product, in particular an oncogene protein, which is replication deficient in cells that do not contain YB-1 in the core and transactivates at least one viral gene, preferably an adenovirus gene. E1B55kDa, E4orf6, E4orf3 and E3ADP. |