| abstract |
The present invention is directed to the rescue of a reverse stranded RNA recombinant virus that expresses a heterologous gene product in an appropriate host cell system and / or expresses, packages, and / or presents the heterologous gene product on the surface. A recombinant bovine parainfluenza virus (bPIV) cDNA or RNA that can be used. More specifically, the heterologous gene product may be a gene product of another parainfluenza virus species or another reverse strand RNA including but not limited to influenza virus, respiratory syncytial virus, human metapneumovirus and avian pneumovirus. Gene products of viruses are included.n n n The chimeric virus and expression products can be effectively used in vaccine formulations including vaccines against a wide range of pathogens and antigens. |