http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-101050256-B1
Outgoing Links
| Predicate | Object |
|---|---|
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-02 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-02 |
| filingDate | 2005-12-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2011-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 2011-07-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-101050256-B1 |
| titleOfInvention | Method of manufacturing Losartan |
| abstract | The present invention relates to an improved process for the preparation of losartan and its potassium salts, which process comprises reacting bromo OTBN with BCFI in the presence of a base and a phase transfer catalyst to produce cyanoaldehyde, in the presence of tributyl tin chloride Reacting the cyano aldehyde with sodium azide to produce an aldehyde tetrazole, reducing the aldehyde tetrazole with sodium borohydride to produce losartan, and preferably a known method for the lossartan Converting to potassium salt.n n n Losartan, tetrazole |
| priorityDate | 2005-08-31-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 92.