| abstract |
The present invention aims at the isolation and identification of vWF specific cleavage enzymes. cleaves the binding of 842 Tyr-843 Met of vWF and comprises a polypeptide chain containing Leu-Leu-Val-Ala-Val as a partial sequence, more suitably Ala-Ala-Gly-GlV-Ile-Leu- N-terminal amino acid partial sequence of the mature protein of His-Leu-Gly-Leu-Leu-Val-Ala-Val, and in one embodiment, a molecular weight of 105 to 160 kDa in SDS-PAGE under reducing or non-reducing conditions. It relates to a vWF specific cleavage enzyme comprising a polypeptide chain having. The isolation and identification of the vWF specific cleavage enzyme opens up the possibility of supplemental therapies for patients with diseases caused by deficiencies of the enzyme, such as thrombotic thrombocytopenic purpura.n n n vWF Factor Cleavage Enzyme, Thrombotic Thrombocytopenic Purpura |